GSK2606414 from MedChemExpress

Product Specs
ItemGSK2606414
CompanyMedChemExpress
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberHY-18072
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.89%
TypeChemical
Molecular Weight451.44
FormulaC₂₄H₂₀F₃N₅O
Research AreaCancer

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(1) Development of a cell-free screening assay for the identification of direct PERK activatorsPLOS ONEMay 18, 2023Márcia F. D. Costa, Günter U. Höglinger, Thomas W. Röslercalcineurin-B (ab103786) were obtained from Abcam (Cambridge, UK). Modifiers of the PERK pathway, GSK2606414 (HY-18072), CCT020312 (HY-119240), TUDCA (tauroursodeoxycholic acid; HY-19696), resveratrol (HY-16561), metformin

(2) PERK/ATF3-Reduced ER Stress on high potassium environment in the suppression of tumor ferroptosisJournal of CancerMay 15, 2023Xufeng Pu, Li Li, Zhenhui Chen, Aihua Gong, Jiao Lei, Lirong Zhang, Hsiang-I Tsai(#HY-100579), Z-VAD-FMK (#HY-16658B), necrostastin-1 (#HY-15760), necrostatin-2 (#HY-14622), GSK2606414 (#HY-18072), and piperazine erastin (#HY-100887) were purchased from MedChemExpress (MCE; Monmouth Junction, NJ,

(3) Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalitiesNPJ Parkinson's diseaseMarch 7, 2023Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H.(an ER stress inducer, Sigma-Aldrich, #T9033), 100 nM GSK2606414 (a PERK inhibitor, MedChemExpress, #HY-18072)66, or 100 nM KIRA8 (an IRE1α inhibitor, MedChemExpress, #HY-114368)67 for 48 or 96 h. For growth factor

(4) African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α PathwayMicrobiology spectrumDecember 21, 2022Zhong H, Fan S, Du Y, Zhang Y, Zhang A, Jiang D, Han S, Wan B, Zhang G.(AF594) were purchased from Invitrogen (Carlsbad, CA). TG (HY-13433), ISRIB (HY-12495), and GSK2606414 (HY-18072) were purchased from MedChemExpress (Monmouth Junction, NJ). Puromycin (P8833), sodium arsenite (S7400),

(5) Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular CarcinomaCellsDecember 1, 2022Li X, Chen Q, Liu J, Lai S, Zhang M, Zhen T, Hu H, Gao X, Wong AST, Zeng JZ.(HY-100844), JNK inhibitor SP600125 (HY-12041), ATF6 inhibitor AEBSF (HY-12821), PERK inhibitor GSK2606414(HY-18072), and p38 inhibitor SB203580 (HY-10256) were purchased from MedChemExpress (Monmouth Junction, NJ, United

(6) Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabeteseLifeMay 12, 2022Pérez-Martí A, Ramakrishnan S, Li J, Dugourd A, Molenaar MR, De La Motte LR, Grand K, Mansouri A, Parisot M, Lienkamp SS, et al.response branches were inhibited individually using the PERK inhibitor GSK2606414 (MedChemExpress, #HY-18072), the IRE1a inhibitor GSK2850163 (Sigma-Aldrich, #1684), and the ATF6 inhibitor Ceapin-A7 (Sigma-Aldrich,

(7) PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleenThe Journal of experimental medicineApril 4, 2022Liu M, Wu C, Luo S, Hua Q, Chen HT, Weng Y, Xu J, Lin H, Wang L, Li J, et al.adenomas by 15–17 wk. For systemic PERK inhibitor treatment, the mice received a dose of 25 mg/kg GSK (HY-18072; MedChemExpress), 12 mg/kg AMG (HY-12661A; MedChemExpress), or vehicle (100 μl of 0.5% hydroxypropyl

(8) The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host celleLifeDecember 6, 2021Dumaine JE, Sateriale A, Gibson AR, Reddy AG, Gullicksrud JA, Hunter EN, Clark JT, Striepen B.drug",Thapsigargin,MedChemExpress,HY-13433,Used 1 µM "Chemical compound, drug",GSK2606414,MedChemExpress,HY-18072,Used 30 nm "Chemical compound, drug",KIRA6,MedChemExpress,HY-19708,Used 500 nm "Software, algorithm",Prism

(9) Knockdown of cytokeratin 8 overcomes chemoresistance of chordoma cells by aggravating endoplasmic reticulum stress through PERK/eIF2α arm of unfolded protein response and blocking autophagyCell death & diseaseNovember 25, 2019Wang D, Zhang P, Xu X, Wang J, Wang D, Peng P, Zheng C, Meng QJ, Yang L, Luo Z.μg/), and 1% (v/v) l-glutamine (Gibco, USA). Doxo (#HY-15142A), Irino (#HY-16562), and GSK2606414 (#HY-18072) were purchased from MedChemExpress (Shanghai, China). The final concentration of dimethylsulfoxide

(10) Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced LatencyCell Host & MicrobeDecember 13, 2017Min Zhang, Julio Gallego-Delgado, Cristina Fernandez-Arias, Norman C. Waters, Ana Rodriguez, Moriya Tsuji, Ronald C. Wek, Victor Nussenzweig, William J. SullivanLtd.,Cat#A2191 Dihydroartemisinin,"AK Scientific, Inc.",Cat#K453 Salubrinal,Tocris Bioscience,Cat#2347 GSK2606414,MedChemexpress,Cat#HY-18072 Amodiaquin,Sigma-Aldrich,Cat#1031004 Atovaquone,Sigma-Aldrich,Cat#A7986 Pyrimethamine,Sigma-Aldrich,Cat#46706 Primaquine,Sigma-Aldrich,Cat#

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GSK2606414 from MedChemExpress

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GSK2606414 from MedChemExpress

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